Reliance Machinery recently completed the installation and commissioning of a 250ml Isoflurane Filling & Capping Line for a leading pharmaceutical manufacturer in Brazil. The project was designed for the automatic filling, capping, and inspection of volatile inhalation anesthetics, ensuring high accuracy, operator safety, and full compliance with GMP requirements.
The customer required a reliable production line capable of handling 250ml amber glass bottles containing isoflurane while maintaining product quality and minimizing anesthetic vapor exposure throughout the production process.
Customer Requirements
The Brazilian pharmaceutical company had several key objectives:
- High filling accuracy for 250ml Isoflurane bottles
- Closed filling system to reduce anesthetic evaporation
- Automatic cap feeding and torque-controlled capping
- Stable production with minimal downtime
- GMP-compliant design for pharmaceutical manufacturing
- Easy cleaning and maintenance
- Future integration with labeling and packaging equipment
After technical discussions, Reliance Machinery engineered a customized Isoflurane Filling & Capping Line tailored to the customer’s production process.
Equipment Configuration
The complete production line includes:
- Automatic bottle unscrambler (optional)
- Bottle infeed conveyor
- Automatic bottle positioning system
- High-precision liquid filling machine
- Automatic cap feeder
- Servo-controlled capping machine
- Bottle inspection station
- Reject system
- Collection conveyor
The system is designed specifically for 250ml amber glass bottles used in inhalation anesthetic packaging.
Technical Specifications：
| Item | Specification |
| Product | Isoflurane |
| Bottle Size | 250ml Amber Glass Bottle |
| Filling Accuracy | ±0.5% |
| Filling System | Ceramic Piston Pump |
| Capacity | Up to 40 Bottles/Minute |
| Cap Type | Screw Cap |
| Control System | Siemens PLC + Siemens HMI |
| Drive System | Servo Motor |
| Machine Material | SUS304 / SUS316L |
| Compliance | GMP |
Key Features of the Isoflurane Filling Line
High Filling Accuracy
Isoflurane is an expensive pharmaceutical anesthetic, making dosing precision critical. The ceramic piston filling system delivers consistent filling volumes while minimizing product waste.
Closed Filling Design
Because isoflurane is volatile, the filling station features a closed design that helps reduce vapor loss and improves workplace safety.
Intelligent No-Bottle-No-Fill Function
Photoelectric sensors ensure that bottles are correctly positioned before filling begins. If no bottle is detected, the machine automatically skips the filling cycle.
Servo-Controlled Capping
The servo capping system applies precise and consistent torque, ensuring secure sealing without damaging caps or bottles.
Automatic Inspection and Rejection
The production line automatically detects:
- Missing bottles
- Missing caps
- Crooked caps
- Improperly sealed bottle
Defective products are rejected automatically without interrupting production.
GMP-Oriented Design
The entire line was designed according to pharmaceutical GMP standards.
Key GMP features include:
| 1 | Stainless steel SUS304/SUS316L construction |
| 2 | Hygienic machine design with smooth surfaces |
| 3 | Easy cleaning and maintenance |
| 4 | Minimal dead corners |
| 5 | Validation-ready architecture |
| 6 | Electronic production data support |
| 7 | Optional 21 CFR Part 11 compliance |
| 8 | Optional Audit Trail and electronic records |
Challenges and Solutions：
Challenge 1: Handling Volatile Liquids
Isoflurane evaporates easily during production.
Solution:
Reliance Machinery designed a sealed filling system that significantly reduces evaporation while maintaining filling accuracy.
Challenge 2: Preventing Bottle Damage
Amber glass bottles are relatively fragile.
Solution:
Servo-controlled bottle indexing ensures smooth transportation without collision.
Challenge 3: Maintaining Stable Torque
Different batches of caps may require slight torque adjustments.
Solution:
The servo capping system allows operators to adjust torque directly from the HMI without mechanical changes.
Customer Benefits
After installation, the Brazilian customer achieved several operational improvements:
- Increased production efficiency
- Reduced product loss
- Improved filling consistency
- Lower labor requirements
- Stable long-term operation
- Easier GMP documentation and validation
The customer also praised the machine’s user-friendly interface, low maintenance requirements, and responsive after-sales technical support.
Why Choose Reliance Machinery?
Reliance Machinery specializes in pharmaceutical liquid filling equipment, including solutions for sterile and non-sterile products. Our expertise includes:
- Isoflurane Filling Machines
- Inhalation Anesthetic Filling Lines
- Eye Drop Filling Machines
- Oral Spray Filling Machines
- Nasal Spray Filling Machines
- Sterile Liquid Filling Systems
- Pharmaceutical Bottle Filling & Capping Machines
Every project is customized according to bottle size, filling volume, production capacity, and regulatory requirements.
Conclusion
This successful 250ml Isoflurane Filling & Capping Line project in Brazil demonstrates Reliance Machinery’s ability to deliver reliable, GMP-compliant pharmaceutical filling solutions for volatile anesthetic products.
Whether you require a standalone filling machine or a complete turnkey production line, our engineering team can provide customized solutions that improve productivity, product quality, and operational efficiency.
Looking for a reliable Isoflurane Filling Machine or Inhalation Anesthetic Filling Line? Contact Reliance Machinery today to discuss your pharmaceutical packaging project.
