{"id":5762,"date":"2026-11-03T14:30:00","date_gmt":"2026-11-03T06:30:00","guid":{"rendered":"https:\/\/pharma-reliance.com\/?p=5762"},"modified":"2026-11-03T14:30:00","modified_gmt":"2026-11-03T06:30:00","slug":"types-of-liquid-filling-system-in-pharma-machine","status":"publish","type":"post","link":"https:\/\/pharma-reliance.com\/it\/types-of-liquid-filling-system-in-pharma-machine\/","title":{"rendered":"Types of liquid filling system in Pharma machine?"},"content":{"rendered":"

The dosing principle decides what the worst case is, which parts drift, and therefore which challenges an OQ must contain. A peristaltic filler and a piston filler can both hit the same target volume and still need quite different qualification protocols.<\/p>\n\n\n\n\n\n\n\n\n\n
Technology<\/td>\nTypical use<\/td>\nWorst case to challenge in OQ Wear or drift item to trend<\/td>\n<\/tr>\n
Piston(volumetric) fillers<\/a><\/td>\nSyrups\uff0c suspensions and other moderate to high viscosity oral Liquids<\/td>\nMost viscous product\uff0c maximum speed\uff0c smallest fill on the largest cylinder Piston seals and valve wear\uff0c visible as a bias that grows overtime<\/td>\n<\/tr>\n
Peristaltic pump fillers<\/a><\/td>\nSterile injectables and smal-volume fils where low hold-up and quick changeover matter<\/td>\nSmallest fill volume\uff0c longest continuous run\uff0c product temperature after every tubing change Tubing lot and hours in use\uff1b re-verify fill weight after every tubing change<\/td>\n<\/tr>\n
Gravity\uff0c time-pressure and overflow(level) fillers<\/td>\nLow-viscosity oral solutions\uff0c mouthwashes\uff0c topical liquids<\/td>\nContainer dimensional variation\uff0c because a level fill delivers a constant height\uff0c not a constant volume Nozzle seals\uff0c and any change of container supplier or mould<\/td>\n<\/tr>\n
Mass-flow or net-weigh fillers<\/td>\nLines that dose by weight or flowmeter<\/td>\nDensity and temperature change across the batch; flowmeter or load-cell calibration\uff0c as-found and as-left<\/td>\n<\/tr>\n
Rotary and monoblock (fil-cap) machines<\/a><\/td>\nHigh-speed bottle and vial Lines\uff0c common in contract manufacturing<\/td>\nMaximum speed\uff0c every format change Star-wheel timing\uff0c closure torque<\/td>\n<\/tr>\n
Aseptic systems(vials\uff0c ampoules\uff0c BFS\uff0c prefilled syringes)<\/td>\nSterile products filled in Grade A RABS or isolators<\/td>\nInterventions\uff0c stoppages and restarts\uff0c aseptic process simulation performance Glove integrity\uff0c decontamination cycle<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"excerpt":{"rendered":"

The dosing principle decides what the worst case is, which parts drift, and therefore which challenges an OQ must contain. […]<\/p>\n","protected":false},"author":1,"featured_media":5502,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_angie_page":false,"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""},"page_builder":"","footnotes":""},"categories":[35],"tags":[149],"class_list":["post-5762","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faq-of-pharma-machine","tag-types-of-liquid-filling-system"],"_links":{"self":[{"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/posts\/5762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/comments?post=5762"}],"version-history":[{"count":4,"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/posts\/5762\/revisions"}],"predecessor-version":[{"id":6021,"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/posts\/5762\/revisions\/6021"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/media\/5502"}],"wp:attachment":[{"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/media?parent=5762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/categories?post=5762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharma-reliance.com\/it\/wp-json\/wp\/v2\/tags?post=5762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}