GMP Pharmaceutical products filling and capping machine
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Types and technical requirements of pharmaceutical filling machines
For practitioners in the pharmaceutical and food industries, filling machines are very common equipment. Why do these industries use filling machines? This comes down to the form of the product and the cleanliness requirements of the product during the production process. Let’s talk about the form of the product first.
Most medicines or food are for human consumption. Because they have high requirements for health, the corresponding cleanliness is also very high. This is not the main thing. The main thing is to prevent secondary pollution, so the production of these industries Most of the processes adopt relatively advanced automated production, which can effectively reduce human input and eliminate pollution.
There are many classifications of filling machines. According to the state of the items being filled, there are fluid filling, powder filling, granular filling, etc. Single fluids also have different viscosities. There are too many subdivisions here. On the contrary, it is easy to confuse the audio and visual. It boils down to liquid, semi-liquid, and solid states, which can be processed by filling machines.
Another subdivision method is also very representative. It is divided according to whether it is quantitative filling. Most of them are quantitative, especially medicines. Not only quantitative but also the accuracy of the determined quantity is very demanding. For example, some oral liquids have to be done quantitatively, and there are many harmful effects of overdosing.
There are also non-quantitative ones, such as industrial glue filling. These are not quantitative. They are simply defined roughly by time or volume. A little more or a little less has no effect.
There are several main types of quantitative control filling. One is fluid, which can be equipped with a flow valve to read data to control the filling process. Some use pressure to control the filling volume, and the quantity is relatively large. There is another It is defined by a quantitative volume container.
Fuzzy control is also a widely used one. For example, in hot water overflow, the height of the water level controls the amount of water. As long as a flow outlet is set up at a fixed height when the water level rises to the flow outlet, the amount will not increase. It will flow out, thereby always maintaining the height of the water level and the amount of water.
The filling method uses gravity and pressure filling, which can save power sources, but the stability is greatly affected by the capacity. Common air pressure quantitative filling is widely used, which is pushed by a pneumatic volume piston. Method filling has formed a standardized system.
In addition, there is also vacuum filling, the most typical of which is the filling of beer and carbonated drinks. Because there are a lot of bubbles inside, the filling head must be inserted into the bottom of the bottle, rising as the liquid level rises, and inside the bottle. Filling with negative pressure can effectively prevent the generation of bubbles, thereby making the quantification more accurate.
As for filling, considering that liquids and other reasons may cause corrosion of the equipment, stainless steel materials are used for all fillings. When steel is not available, food-grade non-metallic materials can be selected, which can be maximized. Reduce pollution.
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