{"id":5439,"date":"2026-10-20T10:17:28","date_gmt":"2026-10-20T02:17:28","guid":{"rendered":"https:\/\/pharma-reliance.com\/?p=5439"},"modified":"2026-10-20T10:33:45","modified_gmt":"2026-10-20T02:33:45","slug":"nitrogen-purge-systems-of-liquid-filling-system","status":"publish","type":"post","link":"https:\/\/pharma-reliance.com\/pt\/nitrogen-purge-systems-of-liquid-filling-system\/","title":{"rendered":"Nitrogen Purge Systems Of Liquid Filling System"},"content":{"rendered":"<h2>1. What is the Nitrogen Purge System<\/h2>\n<p>Nitrogen Purge Systems work with new or existing packaging lines. These systems work to replace oxygen in containers or container headspace to increase shelf life while preserving the flavor, texture and color of the product. Nitrogen purge systems are available for pre-fill, post-fill or pre-can purging.<\/p>\n<h2>2. Features of Nitrogen Purge System<\/h2>\n<table>\n<tbody>\n<tr>\n<td width=\"253\">Pre-Fill, Post-Fill or Pre-Cap Purge<\/td>\n<td width=\"180\">Handles a Variety of Container Shapes &amp; Sizes<\/td>\n<\/tr>\n<tr>\n<td width=\"253\">Conveyor Mounting Packaging or Portable Frame<\/td>\n<td width=\"180\">No Change Parts Necessary for Most Applications<\/td>\n<\/tr>\n<tr>\n<td width=\"253\">Easy Set-Up, Operation and Adjustment<\/td>\n<td width=\"180\">Designed to Integrate with Existing Machinery<\/td>\n<\/tr>\n<tr>\n<td width=\"253\">Tool-Free Adjustmen<\/td>\n<td width=\"180\">Robust Construction for 24\/7 Performance<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2>3. How does the Nitrogen Purge System Work?<\/h2>\n<p>Protect product freshness, taste, texture, and color with Nitrogen Purge Equipment.<\/p>\n<p>Use nitrogen purge machinery between filling and capping to remove oxygen from containers, or container head space, in order to preserve the taste, color and texture of the packaged item. Purging oxygen from the head space of a container after filling can also extend shelf life for many different products by offering protection against oxidation. \u00a0While most nitrogen gas systems are conveyor mounted for use on an automatic packaging line, purging machines can be custom manufactured for unique packaging projects.<\/p>\n<p>&nbsp;<\/p>\n<h2>4. Case Study: Precision Filling and Dual Nitrogen Purging for Liquid Supplement Dropper Bottles<\/h2>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-4926\" src=\"https:\/\/pharma-reliance.com\/wp-content\/uploads\/2026\/10\/probiotic-drops-filling-capping-machine-05.png\" alt=\"\" width=\"850\" height=\"500\" srcset=\"https:\/\/pharma-reliance.com\/wp-content\/uploads\/2026\/10\/probiotic-drops-filling-capping-machine-05.png 850w, https:\/\/pharma-reliance.com\/wp-content\/uploads\/2026\/10\/probiotic-drops-filling-capping-machine-05-800x471.png 800w, https:\/\/pharma-reliance.com\/wp-content\/uploads\/2026\/10\/probiotic-drops-filling-capping-machine-05-768x452.png 768w, https:\/\/pharma-reliance.com\/wp-content\/uploads\/2026\/10\/probiotic-drops-filling-capping-machine-05-18x12.png 18w\" sizes=\"(max-width: 850px) 100vw, 850px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Application:<\/strong> Supplement ( Probiotic, Vitamin Drops, D3K2, Omega 3 Oil)<\/p>\n<p><strong>Filling Volume:<\/strong> 10ml, 15m, 20ml, 30ml<\/p>\n<p><strong>Container:<\/strong> Amber Glass Dropper Bottle with reducer and screw cap<\/p>\n<p><strong>Nitrogen Purge System:<\/strong> Before Filling Station and After Filling Station ( before Capping Close)<\/p>\n<p>&nbsp;<\/p>\n<h3>4.1 Project Overview<\/h3>\n<p>Shanghai Reliance Machinery developed a customized liquid filling and capping solution for nutritional supplements, including probiotics, vitamin drops, D3K2 formulations, and Omega-3 oils. The system handles 10 ml, 15 ml, 20 ml, and 30 ml amber glass dropper bottles equipped with reducer inserts and screw caps.<\/p>\n<p>A key project requirement was to maintain consistent filling accuracy while minimizing oxygen exposure during packaging. To address this challenge, the machine integrates two nitrogen purging stations: one before filling to reduce oxygen inside empty bottles, and another after filling, immediately before capping, to reduce residual oxygen in the bottle headspace.<\/p>\n<h3>4.2 Engineering Solution: Accurate Dosing and Nitrogen Control<\/h3>\n<p>To maintain consistent filling volumes across multiple bottle sizes, the filling system uses adjustable dosing parameters and a controlled filling cycle. The filling volume is calibrated for each product format, while repeatability is verified through sample weighing or volumetric testing. Filling speed, liquid viscosity, nozzle positioning, and anti-drip performance are evaluated to minimize splashing, dripping, and dosing variation.<\/p>\n<p>The dual nitrogen purging system provides additional protection for oxidation-sensitive formulations. Before filling, nitrogen is introduced into the empty amber glass bottles to displace part of the air. After filling, a second controlled nitrogen purge is applied to the headspace before the reducer insert and screw cap are secured. Nitrogen flow, purge duration, nozzle position, and timing are adjusted according to the bottle geometry and product characteristics.<\/p>\n<p>The target residual oxygen concentration in the finished bottle headspace is <strong>4%\u20136%,<\/strong> verified through headspace oxygen testing. This range serves as the project&#8217;s process-control target and should be confirmed through production trials and product stability studies.<\/p>\n<h3>4.3 Project Results and Benefits<\/h3>\n<p>The integrated solution supports flexible production of 10\u201330 ml liquid supplements while improving filling consistency and reducing oxygen exposure during packaging. By coordinating precise dosing, two-stage nitrogen purging, and prompt closure, the system helps manufacturers manage oxidation risks in sensitive liquid formulations.<\/p>\n<p>For reliable production, filling accuracy and headspace oxygen are evaluated as separate control parameters. Final acceptance criteria are established using actual product samples, repeatability testing, residual oxygen measurements, and stability data under the intended storage conditions.<\/p>\n<p><strong><b>Shanghai Reliance Machinery <\/b><\/strong>provides customized liquid supplement filling and capping equipment designed around product properties, bottle formats, and process requirements.<\/p>\n<h3><\/h3>\n<h3>4.4 Working Video Of Probiotic Drops Filling Capping Machine with Nitrogen Purge System<\/h3>\n<p>&nbsp;<\/p>\n<p><iframe title=\"RELIANCE RPL GMP 10ML, 15ML Vitamin Drops D3K2 Amber Bottle Filling Capping Labeling Packing Line\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/cakBVW1bl1U?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<h3>5. <a href=\"https:\/\/pharma-reliance.com\/pt\/entre-em-contato-conosco\/\">Learn More about Monoblock vitamin drops filling capping machine;<\/a><\/h3>\n<blockquote class=\"wp-embedded-content\" data-secret=\"tRisxtx2LX\"><p><a href=\"https:\/\/pharma-reliance.com\/pt\/products\/vitamin-drops-filling-capping-machine\/\">Vitamin Drops Filling Capping Machine<\/a><\/p><\/blockquote>\n<p><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u300a Vitamin Drops Filling Capping Machine \u300b\u2014pharma-reliance.com\" src=\"https:\/\/pharma-reliance.com\/products\/vitamin-drops-filling-capping-machine\/embed\/#?secret=6Ba4K7v3VH#?secret=tRisxtx2LX\" data-secret=\"tRisxtx2LX\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<h4>Machine Specification:<\/h4>\n<ol>\n<li>Capacity: 60 bottles\/min<\/li>\n<li>Filling Range: 10 -30ml<\/li>\n<li>Filling System: Prestaltic Pump + anti drippping nozzles ( 4 Station )<\/li>\n<li>Cappping System: All servo control for cap close torque<\/li>\n<li>Optional: Nitrogen Filling before filling station, and before capping station<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000080;\"><strong>Contato <a href=\"https:\/\/pharma-reliance.com\/pt\/entre-em-contato-conosco\/\">RELIANCE Sales Team<\/a> to learn more about the purge system and how nitrogen can benefit your packaging project.<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2>6. What kind of products need Nitrogen Purge System on filling machine?<\/h2>\n<p>&nbsp;<\/p>\n\n<table id=\"tablepress-1\" class=\"tablepress tablepress-id-1\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Liquid Product Types<\/th><th class=\"column-2\">Is it advisable to consider nitrogen flushing?<\/th><th class=\"column-3\">Primary Objectives<\/th><th class=\"column-4\">Common Applications<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">Liquid probiotics<\/td><td class=\"column-2\">Depends on the strain and formulation<\/td><td class=\"column-3\">Reduce oxygen exposure to help maintain viable cell counts<\/td><td class=\"column-4\">Liquid formulations of *Bifidobacterium* and certain *Lactobacillus* species<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">Medicinal oils<\/td><td class=\"column-2\">Generally worth evaluating<\/td><td class=\"column-3\">Minimize oxidation, discoloration, and the degradation of active ingredients<\/td><td class=\"column-4\">Oxidation-prone medicinal oils and fat-soluble preparations<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">Liquids containing unsaturated fatty acids<\/td><td class=\"column-2\">Generally worth considering<\/td><td class=\"column-3\">Reduce lipid oxidation and rancidity<\/td><td class=\"column-4\">Liquid formulations of fish oil and Omega-3 fatty acids<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">Liquid vitamin preparations<\/td><td class=\"column-2\">Depends on the formulation<\/td><td class=\"column-3\">Decrease the loss of active ingredients caused by oxidation<\/td><td class=\"column-4\">Certain preparations containing vitamins A, C, or E<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">Oxidation-prone oral liquids<\/td><td class=\"column-2\">Depends on the formulation<\/td><td class=\"column-3\">Mitigate oxidative reactions and changes in color or odor<\/td><td class=\"column-4\">Oral solutions containing oxygen-sensitive active ingredients<\/td>\n<\/tr>\n<tr class=\"row-7\">\n\t<td class=\"column-1\">Traditional Chinese medicine extracts and botanical extracts<\/td><td class=\"column-2\">Depends on the ingredients<\/td><td class=\"column-3\">Reduce certain oxidative reactions<\/td><td class=\"column-4\">Oxidation-prone botanical extract preparations<\/td>\n<\/tr>\n<tr class=\"row-8\">\n\t<td class=\"column-1\">Injectables and biological preparations<\/td><td class=\"column-2\">Depends on the specific product<\/td><td class=\"column-3\">Protect oxygen-sensitive components<\/td><td class=\"column-4\">Certain injectable solutions and protein-based preparations<\/td>\n<\/tr>\n<tr class=\"row-9\">\n\t<td class=\"column-1\">Essential oils and certain liquid cosmetic products<\/td><td class=\"column-2\">Depends on the formulation<\/td><td class=\"column-3\">Lower the oxidation of aroma compounds and oils\/fats<\/td><td class=\"column-4\">Essential oils and skincare products containing unsaturated fats<\/td>\n<\/tr>\n<tr class=\"row-10\">\n\t<td class=\"column-1\">Edible oils and nutritional oils<\/td><td class=\"column-2\">Generally worth considering<\/td><td class=\"column-3\">Reduce the oxidation of oils\/fats<\/td><td class=\"column-4\">Olive oil, flaxseed oil, and fish oil<\/td>\n<\/tr>\n<tr class=\"row-11\">\n\t<td class=\"column-1\">Coffee and various beverages<\/td><td class=\"column-2\">Depends on the product and packaging process<\/td><td class=\"column-3\">Minimize oxidation and the loss of flavor<\/td><td class=\"column-4\">Liquid coffee and various oxygen-sensitive beverages<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"excerpt":{"rendered":"<p>1. What is the Nitrogen Purge System Nitrogen Purge Systems work with new or existing packaging lines. These systems work [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4377,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_angie_page":false,"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""},"page_builder":"","footnotes":""},"categories":[34],"tags":[130],"class_list":["post-5439","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-case-study","tag-nitrogen-purge-systems"],"_links":{"self":[{"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/posts\/5439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/comments?post=5439"}],"version-history":[{"count":9,"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/posts\/5439\/revisions"}],"predecessor-version":[{"id":5447,"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/posts\/5439\/revisions\/5447"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/media\/4377"}],"wp:attachment":[{"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/media?parent=5439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/categories?post=5439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharma-reliance.com\/pt\/wp-json\/wp\/v2\/tags?post=5439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}