Roatry Washing Machine For Glass Vials
RELIANCE Pharma Empty Sterile Glass Vials Rotary Washing Machine is an advanced vial cleaning solution designed for pharmaceutical sterile filling applications. The machine provides automated internal and external washing of empty glass vials using rotary motion, precision vial handling, purified water, WFI, and sterile compressed air. It helps pharmaceutical manufacturers achieve consistent container cleanliness before sterilization and aseptic filling.
Designed according to GMP pharmaceutical equipment principles, the rotary vial washer features stainless steel construction, reliable operation, flexible format changeover, and customizable washing processes. It is widely used in sterile injectable production lines for vaccines, biologics, lyophilized products, and other parenteral medicines. RELIANCE provides customized vial washing solutions according to production capacity, vial specifications, and complete filling line requirements.
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DESCRIPTION
The Pharma Empty Sterile Glass Vials Rotary Washing Machine is a high-performance pharmaceutical vial cleaning system designed for washing empty glass vials before sterilization and aseptic filling processes. It is widely used in sterile injectable production lines for vaccines, biologics, lyophilized products, and other parenteral applications.
The machine adopts continuous rotary motion with precision vial handling, internal and external washing stations, and multiple cleaning media options including purified water, WFI (Water for Injection), and sterile compressed air. The system effectively removes glass particles, dust, and foreign contaminants from vial surfaces to ensure clean container preparation before filling.
Designed with GMP/FDA construction, stainless steel materials, and flexible format changeover, the automatic rotary vial washing machine can be customized according to vial size, production capacity, and sterile filling line requirements.
SPECIFICATION
1. Continuous Rotary Washing System
The rotary vial washing machine uses a continuous rotary mechanism with controlled vial transfer. Special grippers hold vials securely by the neck, invert them into a washing position, and complete internal and external cleaning before returning them to the upright position.
2. Multi-Stage Internal & External Cleaning
The machine can be configured with multiple washing cycles, including:
Recycled water washing
Purified water washing
WFI washing
Sterile compressed air drying
Multiple washing stages improve particle removal efficiency and prepare vials for sterilization and aseptic filling.
3. GMP Hygienic Design
Stainless steel construction
Product-contact parts made of pharmaceutical-grade materials
Smooth surface design for easy cleaning
Reduced contamination risk
Suitable for pharmaceutical cleanroom environments
4. High Precision Vial Handling
Neck gripping system prevents vial damage
Stable rotary movement
Accurate vial positioning
Suitable for high-speed sterile filling lines
5. Flexible Customization
The machine can be customized according to:
Vial diameter and height
Production speed
Washing sequence
Cleanroom layout
Integration with depyrogenation tunnel and filling line
| Parameter | RWB-60 | RWB-100 | RWB-120 |
| Number of Gripper | 60 | 100 | 120 |
| Output (Vials/min): 10ml | 180~200 | 400 | 500 |
| Installed Power | 220/380V, 50/60Hz, 16kW | ||
| Main Drive | 0.75kW | ||
| Heater (Option) | 9kW | ||
| Washing Fluid Consumption | 10 L/min | 12 L/min | 15 L/min |
| Washing Fluid Temperature | 50~60℃ | ||
| Washing Fluid Pressure | 1.5~2 kg/cm² | ||
| Compressor Air Consumption | 35 L/min | ||
| Compressor Air Pressure | 3~5 kg/cm² | ||
| Length | 1950 mm | 3200 mm | 3200 mm |
| Width | 1900 mm | 2280 mm | 2280 mm |
| Height | 1750 mm | 1570 mm | 1570 mm |
| Weight | 2000 kg | 2200 kg | 2500 kg |
Häufig gestellte Fragen
Q1: What is a rotary vial washing machine used for?
A rotary vial washing machine is used to clean empty pharmaceutical glass vials before sterilization and sterile filling. It removes particles, dust, and contaminants to improve container cleanliness.
Q2: How does a pharmaceutical vial washing machine work?
The machine automatically feeds vials, grips them by the neck, rotates them into an inverted position, and performs internal and external washing using water and sterile air cycles.
Q3: What types of vials can be cleaned by this machine?
The pharma vial washing machine can be customized for different glass vial sizes, commonly used for injectable drugs, vaccines, biologics, and lyophilized products.
Q4: Does the rotary vial washer meet GMP requirements?
Yes. The machine is designed with GMP-oriented features, including stainless steel construction, hygienic design, controlled cleaning processes, and pharmaceutical-grade components.
Q5: Can the vial washing machine be integrated with a sterile filling line?
Yes. The machine can be connected with vial depyrogenation tunnels, sterile filling machines, stoppering machines, and capping systems to create a complete aseptic filling production line.
QUALIFICATION
Sterile pharmaceutical preparations as injections are filled in glass vials. These vials should be cleaned properly before filling. Automatic vial washing machines are used to clean, but the process of cleaning the vials should be validated. The efficiency of these machines is verified by the following tests.
1.Chloride Content Test:
A 30% solution of sodium chloride is prepared in water. 10 containers or vials are spiked with 0.1 mL of this sodium chloride solution. Containers are swirled to coat the inner surface and evaporate the solution to dryness atroom temperature. Spiked test containers are marked in series with a permanent marker on the outer surface.
2.Particulate Matter Test:
10 gm of charcoal is dissolved to make 1% charcoal slurry. Approximately0.1 ml of charcoal slurry is used to spike each of 10 containers by swirling the container to coat the inner surface and evaporate the solution to dryness at room temperature. Spiked test containers with charcoal are marked in series with a permanent marker on the outer surface.
3.Bacterial Endotoxin Test:
Add 100 endotoxin units into 10 vials and allow them to dry at 45 – 50°C. Mark these spiked vials with permanent marker on the outer surface.
Separate 10 containers are used for each of the above tests
4.Procedure:
About 3000 vials of the selected size are loaded on the feed belt, and vial washing machine is operated as per the standard operating procedure. Place the spiked vials marked with a permanent marker in between the other vials while the machine is running. These vials should be placed at the initial, middle, and end of the washing session. Collect the marked vials after washing and store properly to avoid theother contamination from the environment. These spiked vials are analyzed separately. it should be done three times for each vial size.
5.Acceptance Criteria:
Sodium chloride content should be absent in any of the spiked vials.
Vials should be free from foreign particles & fibers on visual inspection. 10u particles should not be more than 25, and 25u particles should not be more than 3. Vials should comply with the endotoxin limit i.e 0.25 EU/vial.
